Plato: Socrates, have you ever experienced pain before?
Socrates: Indeed, I have, my dear Plato. Pain is a natural part of the human experience. But sometimes I wonder if it’s just my body’s way of reminding me that I’m not as young as I used to be.
Plato: I know the feeling. Speaking of pain, I was just in a hemp store and someone asked the clerk if cannabis can help with pain. Do you have any thoughts on that, Socrates?
Socrates: Ah, cannabis. The plant has been used for medicinal purposes for thousands of years. It contains compounds called cannabinoids that have been shown to have pain-relieving properties. In fact, some of the ancient Greek physicians used cannabis for pain relief.
Plato: Really? I had no idea. But why is it not widely used for pain relief?
Socrates: Well, my dear Plato, the prohibition of cannabis in the middle of the 20th century has arrested cannabis research. In recent years, there has been a growing debate about the use of cannabis for medical purposes. It’s a shame, really. I mean, I know I would appreciate some pain relief every now and then.
Plato: Yes, I’m sure we all would. But is it safe to use?
Socrates: Adverse effects in the short-term medical use of cannabis are generally mild to moderate, well-tolerated, and transient. However, there are scant data regarding the long-term safety of medical cannabis use. But let’s be honest, my dear Plato. Every medicine has its side effects. I mean, even water can be lethal if you drink too much of it.
Plato: I suppose you’re right. But what about its effectiveness in treating pain?
Socrates: A recent meta-analysis of clinical trials of medical cannabis for chronic pain found substantial evidence encouraging its use in pharmacotherapy of chronic pain. However, controlled comparative studies on the efficacy and safety of cannabis/cannabinoids and other analgesics, including opioids, are missing. Further studies examining specific cannabinoids and strains of cannabis, using improved and objective pain measurements, appropriate dosages and duration of treatment in homogeneous patient populations, are needed to determine the long-term efficacy and safety of cannabis/cannabinoids.
Plato: Thank you, Socrates. Your insight is truly enlightening.
Socrates: It is always a pleasure to discuss matters of the body and mind with you, my dear Plato. And who knows, maybe one day we’ll be able to walk into a store and buy some cannabis for pain relief without any fuss.
Plato: Well, actually Socrates, in some states, like ours, we can already do that. There are stores that specialize in selling hemp-derived CBD products, like PhenomWell CBD Store, which is just down the street.
Socrates: Ah, but there’s still so much debate about the use of cannabis for medical purposes. And as we’ve discussed, the long-term safety and efficacy of cannabis/cannabinoids need to be further studied.
Plato: That may be true, but at least we have options. And with more research and regulation, who knows where we’ll be in the future.
Socrates: Indeed, my dear Plato. The pursuit of knowledge and understanding is a never-ending journey.
Written by ChatGPT, based on Cannabinoids and Pain: New Insights From Old Molecules